Fenbendazole is a broad-spectrum benzimidazole anthelmintic used against gastrointestinal parasites including: giardia, roundworms, hookworms, whipworms, the tapeworm genus Taenia, pinworms, aelurostrongylus, paragonimiasis, strongyles, and Strongyloides that can be administered to sheep, cattle, horses, fish, dogs, cats, rabbits, most reptiles, freshwater shrimp tanks as planaria and hydra treatments, as well as seals.
Many drugs are commonly prescribed for off-label use in veterinary medicine. In these instances, follow your veterinarian’s directions and cautions very carefully. Fenbendazole should be given with food to reduce gastrointestinal upset.
Mechanism of Action
Fenbendazole primarily inhibits tubulin polymerization and promotes microtubular (MT) disruption in parasite cells. Tubulin, a structural protein of microtubules, is the leading molecular target of benzimidazoles and has prominent functions in cell proliferation, motility, division, the intercellular transport of organelles, the maintenance of the cell shape, and the secretion process of cells in all living organisms. By binding with beta-tubulin, Fenbendazole blocks microtubular polymerization in worms and thus perturbs glucose uptake, eventually emptying glycogen reserves and adversely affecting energy management mechanisms. As a result, the whole process eventually contributes to the death of the parasites.
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