Sitagliptin and Metformin HCL are the active ingredients in Istamet 50+1000mg. It is an anti-hyperglycemic or anti-diabetic drug that contains DPP-4 inhibitors and is administered orally to help reduce blood sugar. Sitagliptin works by reducing high blood glucose levels. These drugs increase the secretion of insulin and decrease the release of glucagon by the pancreas. This keeps the blood glucose levels at normal levels. When the blood glucose levels become normal, the increased glucagon and insulin changes stop, preventing hypoglycemic situations. Metformin Hcl is an anti-hyperglycemic agent that decreases glucose production from the liver, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing glucose uptake and utilization. The medicine comes in tablet form and has various strengths, including Istamet 50+500 mg and Istamet 50+1000mg tablets. Sun Pharma, India, manufactures this medicine.