Mebenstar 100 (Mebendazole 100mg)

Mebenstar 100 (Mebendazole 100mg)


Manufacturer: Apex
Active ingredient: Mebendazole 100mg
Dosage Form: Tablet/Oral
Pack Size: 1 x 10

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Mebendazole is a typical, broad-spectrum benzimidazole used for more than 40 years in humans to treat various parasitic infestations. It has FDA approval for the treatment of patients greater than two years of age with gastrointestinal infections caused by Necator americanus or Ancylostoma duodenale (hookworms), Ascaris lumbricoides (roundworms), Enterobius vermicularis (pinworms), and Trichuris trichiura (whipworms) in single or mixed infections.

It also has several off-label uses for adult intestinal nematode infection caused by capillariasis; echinococcosis, cystic (Echinococcus granulosus); toxocariasis; trichinellosis (Trichinella spiralis); trichostrongyliasis.

Mebendazole is a new purposed drug in oncology with a focus on cells resistant to approved therapies. Mebendazole exhibits cytotoxic activity, which synergizes with ionizing radiations and different chemotherapeutic agents and stimulating an antitumoral immune response. Recent studies have shown mebendazole is also a better replacement for vincristine to treat brain tumors in animal models.

Mechanism of Action
Mebendazole acts by inhibiting the production of microtubules via binding to colchicine binding-site of β-tubulin and thereby blocking polymerization of tubulin dimers in the intestinal cells of parasites.[5] Consequently, glucose uptake and the digestive and reproductive capacities of parasites are interrupted, resulting in immobilization, hindrance of egg production, and death of the helminth. Mebendazole is poorly absorbed in the digestive tract making it an effective medication for managing intestinal helminthic infections with very few side effects.

There is a possibility for the development of resistance to mebendazole. The mechanism of resistance to benzimidazole is most likely due to changes in β-tubulin protein, which decreases the binding of mebendazole to β-tubulin.[6]

Mebendazole is administered orally without regard to meals. The patient must chew the tablet completely before swallowing. For patients who have difficulty taking the tablet, it can be placed in a spoon and mixed with 2 to 3 ml of drinking water using a dosing syringe. The pill absorbs the water and turns into a soft mass with semi-solid consistency, which is easily swallowable.

Dosing of mebendazole for common FDA indications are listed below:

Roundworm (Ascaris lumbricoides): 100 mg twice daily (morning and night) for three consecutive days.
Hookworm (Ancylostoma duodenale): 100 mg twice daily (morning and night) for three consecutive days
Whipworm (Trichuris trichiura): 100 mg twice daily (morning and night) for three consecutive days
Pinworm (Enterobius vermicularis): 100-mg single oral dose
If the patient does not achieve satisfactory results after three weeks of medication, then a second course of therapy is recommended. Dosing of mebendazole for common non-FDA approved indications are listed below:

Capillariasis Infection: 200 mg to be administered orally twice daily for 20 days
Cestodes Infection: 300 mg to be administered orally twice daily for 3 to 6 days
Filariasis: 300 mg to be taken orally daily for 28 to 45 days

Less than ten (10%) of the drug undergoes systemic absorption after oral ingestion, and this portion undergoes metabolism rapidly by hepatic enzymes. Plasma levels may also decrease by carbamazepine or phenytoin or any CYP450 inducer. Cimetidine does not appreciably raise serum mebendazole, which is consistent with its poor systemic absorption.[10] Mebendazole is largely metabolized primarily by the liver. Higher plasma levels of mebendazole will occur in patients with impaired liver function or decreased biliary excretion. The half-life of mebendazole is around 3 to 6 hours after oral administration. Mebendazole excretion occurs mostly in bile or urine.

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